Presence of metabolic syndrome induced by different concentrations of lead in rats

Background. Lead and other environmental agents can produce, by biochemical mechanisms, alterations in carbohydrate and lipid profile and generate high blood pressure, which is produced by direct injury in endothelium and/or indirect kidney damage.
Objectives. To determine the presence of biochemical, anthropometric components and elevation of blood pressure as constituent elements of metabolic syndrome in rats treated with different concentrations of lead.
Material and method. We worked with Wistar rats, treated with 25, 100, 250, 500, 1000 ppm of lead acetate in drinking water at different times depending on the concentration of lead and other group of metal-free water (control) (n=6 each group). Toxicological laboratory: ALA-D (Delta-aminolevulinic acid dehydratase) and lead in blood. Plasmatic determinations of triglycerides, total cholesterol, HDL cholesterol, glycosylated hemoglobin (Hb) and glucose were done. Systolic blood pressure and weight were measured.
Results. All rats treated with different concentrations of lead presented an increase in weight. Glucose, total cholesterol, triglycerides were elevated in treated groups with 25, 500 and 1000 ppm, not so in controls, the same thing happened with glycosylated Hb (p<0.03). A decrease in HDL cholesterol was observed. Blood pressure was raised in all lead treatments groups and not in control group (p<0.03). In lead highest concentration, all the constituent elements of the studied metabolic syndrome suffer increasingly modifications.
Conclusions. Lead in different doses modifies the normal functioning of lipids metabolism and their respective concentrations of serum; inducing metabolic syndrome, it would be one of unconventional, atherosclerotic cardiovascular disease risk factors.

Keywords: Metabolic syndrome; Lead; Experimental model