CONTENTS

EDITORIAL
Sergio V. Perrone
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REVIEW ARTICLE
Management of the frail patient with advanced heart failure and reduced ejection fraction
Marcia Zuloaga Puglisi, Nicolás Renna
Keywords: Heart failure - Advanced heart failure - Reduced ejection fraction - Frailty - Pathophysiology - Physical rehabilitation - Cardioverter defibrillator - Cardiac resynchronization therapy - Ventricular assist devices - Heart transplant - Polypharmacy - Palliative care
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UPDATE ARTICLE
Is immunity the cause or consequence of a neglected cardiomyopathy in the 21st century?
A vision of Chagas disease
René Padilla, Michael Salamé, Andrés Triana
Keywords: Trypanosoma cruzi - Chagas disease - Pathophysiological mechanisms - Chagasic cardiomyopathy - Immunological mechanisms - G-protein coupled receptors - Adrenergic autoantibodies - Antimuscarinic antibodies
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